Pierce's disease on grapevines

Thomas Miller

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Research Specialization

Thomas A. Miller

I am responsible for teaching insect physiology and toxicology. My research started on the physiology of the insect circulatory system then switched to insect neurophysiological techniques aimed at describing the mode of action of neurotoxic insecticides. I briefly studied insecticide resistance in cotton pests coinciding with the introduction of synthetic pyrethroids, and then worked on the physiology of cotton pests, especially diapause in the pink bollworm, Pectinophora gossypiella (Saunders). I was asked by USDA-APHIS to explore strategies for improving the sterile insect technique for controlling pink bollworm by replacing radiation with conditional lethal genes. In the summer of 2004 we created our first transgenic pink bollworm with a functioning lethal RIDL gene supplied by Luke Alphey of Oxford University. Our collaborators in USDA-APHIS have applied for permits to field release these transgenic insect strains meant for population suppression. Work on insect transformation brought us in contact with Professor Frank Richards at Yale Medical School who pioneered paratransgenesis for use in disrupting insect-vectored transmission of human diseases. Frank suggested that paratransgenesis could be used to control any insect-vectored plant disease in California. Dave Lampe of Duquesne University in Pittsburgh in 2004 created our first transgenic symbiotic bacteria that produce a lethal gene product that neutralizes the pathogenic bacterium, Xylella fastidiosa that is carried by leafhoppers and causes Pierce’s disease in grapevines. We call this new strategy, Symbiotic Control. The Environmental Protection Agency calls this a microbial pesticide.

 

Experts on Demand

 

Degrees

BA Mathematics/Physics 1962
University of California, Riverside
PhD Entomology 1967
University of California, Riverside
 

Awards

2010 U.S. Department of State, National Academies Jefferson Science Fellow 
2006 - Plenary Lecturer, International Symbiosis Congress, Vienna 
2005 - Verrall Lecturer, Royal Entomological Society, London
2004 - Plenary Lecturer, Plant Protection Congress, Beijing 
2004 - G.J. Mendel Honorary Medal for Merit in the Biological Sciences, from the Academy of Sciences of the Czech Republic
1986 - NAS Eastern European Exchange Program 
1978 - 1979 National Academy of Sciences Eastern European Exchange Program
1968-69 - NATO Fellow
 

Mendel Award Ceremony 2003

 

 

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